Thus, not all ovarian tumors are cancers Cystadenocarcinomas have a thick, shaggy lining due to inflammation, edema and overcrowding of the epithelial cells. Appearance of the ovary depends widely on the age / menopausal state: Newborn ovaries are elongated and approximately 1.3 cm in greatest dimension, Ovaries enlarge during infancy and childhood and reach adult size and shape by the time of puberty, Neonatal ovaries often have cysts, which resolve spontaneously (, 3 - 5 cm long and weigh 5 - 8 g; size and weight depend on the amount of follicular derivatives (cysts and corpora albicantia / lutea), Pink-white exterior is initially smooth but gradually becomes more convoluted, Cystic follicles and corpora lutea may be visible from outside, Cut section may exhibit 3 zones: cortex, medulla and hilus, with follicular derivatives usually in the cortex and medulla, Firm consistency with solid, pale cut surface, Occasional cysts measuring several millimeters in diameter (inclusion cysts) may be discernible within the cortex, Small white scars (corpora albicantia) are typically present within the medulla, Thick walled blood vessels may be appreciable within the medulla and the hilus, Arterial supply: approximately 10 arterial branches from anastomotic arcade of ovarian artery (branch of aorta) and ovarian branch of uterine artery penetrate hilus into medulla and cortex, Venous drainage: left ovarian vein drains to left renal vein, right ovarian vein drains to inferior vena cava, Lymphatic drainage: originates predominantly from theca layer of follicles, exiting through the hilus, to the mesovarium, along the infundibulopelvic ligament, into upper paraaortic lymph nodes; may bypass to internal iliac, external iliac, common iliac, sacral, obturator, pelvic, retroperitoneal or inguinal nodes, Enlarged corpus luteum cyst can trigger an intraoperative consultation; the cyst lining is yellow and has a convoluted appearance, Luteoma of pregnancy can be discovered incidentally during cesarean section or preoperatively on imaging study mimicking an ovarian mass (. Pathology Outlines - High grade serous carcinoma Each category includes a number of subtypes. In majority of the cases, the tumor is present as a single mass within the ovary; though rarely, the tumor can occur as multiple masses within a single ovary, or it may affect both the ovaries . Definition / general #5 cause of cancer death in women (after lung, breast, colon, pancreas); incidence has not changed recently (15,500 estimated US deaths in 2012, American Cancer Society) Poor prognosis. Pathological Aspects. This website is intended for pathologists and laboratory personnel but not for patients. [2] Precursors lesions: Serous borderline tumours for low-grade serious carcinoma. Ovary - Libre Pathology The most frequent primary sites that metastasize to the ovary are: 45% from the gastrointestinal tract, 20% from the pancreas, 18% from the cervix and endometrium, and 8% from the breast [17,18].It is agreed that diagnosing primary MOC requires careful . The pathology of the major types of ovarian cysts: follicular and luteal. It usually occurs as a combination of cystic and solid mass within the ovary. and Krisztina Hanley, M.D. Peritoneal route of spread of ovarian cancer, Ovarian carcinoma cells in cervical aspirate, Ovarian tumor cells, psammomabody in cervicalsmear, Ovarian carcinoma cells in peritoneal fluid. ovary anatomy[TIAB] OR ovary histology[TIAB], Endotext: Morphology and Physiology of the Ovary [Accessed 9 September 2021], Endocrinol Metab Clin North Am 1998;27:877, Paired female reproductive glands located on each side of the uterus, adjacent to the lateral pelvic wall, posterior to the broad ligament and anterior to the rectum, Originate from the genital ridge formed by the thickening of the coelomic epithelium with oogonia later migrating from the yolk sac endoderm (, Paired ovoid organs located on each side of the uterus, Responsible for the development of the dominant follicle and the production of hormones, Multiple histologic components can be seen in the normal ovaries and can mimic pathologic findings, Function first described by Reinier de Graaf (, Ovaries play an essential role in the fertility and cycling of reproductive activity in women, mainly by controlling the development of the dominant follicle and producing hormones (estrogen and progesterone) (, Folliculogenesis starts by recruiting primordial follicles into growing follicles that eventually proceed either to ovulation or death, Folliculogenesis is divided into preantral (growth and differentiation of follicles) and antral phase (increase in the follicle size), Folliculogenesis will result in the production of a single dominant follicle (Graafian follicle), which will eventually ovulate, ~400,000 primordial follicles containing primary oocytes are present at birth in ovarian stroma (100,000 at gestational age of 15 weeks; 680,000 at 8 months) (, Follicular decay appears to advance with increasing age; prominent cystic follicles are present at birth and at puberty (, Germ cells travel from yolk sac endoderm to ovary where they develop into oogonia and oocytes, arresting at prophase of mitosis, Ovulation: induces cyclic rupture and regenerative repair of the ovarian surface epithelium, Following ovulation, the dominant follicle becomes the corpus luteum responsible for the production of progesterone during the luteal phase of each menstrual cycle or becomes the corpus luteum of pregnancy to sustain gestation, Hormones produced by the dominant follicle are essential for the preparation of the uterus for implantation of the embryo (, Hilus cells produce steroids (predominantly androstenedione); resemble Leydig cells of testis; may produce masculinizing tumors (hilus cell tumors), Characteristic streak gonads in patients with Turner syndrome, also known as congenital ovarian hypoplasia, due to monosomy X (45,XO); these are not functional and will subsequently manifest with symptoms of ovarian failure (, Primary ovarian insufficiency: a condition diagnosed in women less than 40 years of age and characterized by depletion or dysfunction of the ovarian follicles with subsequent impaired ovarian function (, Tests that evaluate the ovarian function usually done in the context of primary or secondary amenorrhea or infertility problems (, These tests include but are not limited to, Measurement of follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels, Estrogen production: serum 17 beta estradiol level, Along its anterior (hilar) margin to posterior aspect of broad ligament by mesovarium (double fold of peritoneum), At its medial pole to ipsilateral uterine cornu by utero-ovarian ligament, At superior aspect of lateral pole to lateral pelvic side wall by infundibulopelvic (suspensory) ligament, Laterality in a hysterectomy and bilateral salpingo-oophorectomy specimen established based on the, Utero-ovarian ligament, which connects each ovary to the ipsilateral uterine cornu and is situated posterolateral and inferior to the attachment of the fallopian tubes, Posterior peritoneal reflection, which extends over a longer segment of the uterus compared to the anterior surface, which has a longer roughened area. Introduction. ovary pathology It has benign tumours and malignant ones. the , . Layering of epithelial cells (stratification). Hemorrhagic Cyst Of Ovary Pathology Outlines Located in ovarian hilus, undulating epithelium, smooth muscle wall, cyst lining is a single layer of flat cuboidal cells, Nests of Leydig cells may be present in the wall, Paramesonephric cyst attached to fimbria, thin fallopian tube type epithelium with small epithelial plicae projecting into the lumen, may have smooth muscle in the wall, Lined by mesothelial cells, often associated with ovarian surface adhesions, Lined by cuboidal cells and usually surrounded by smooth muscle, Lined by a single layer of mucin containing tall columnar epithelium, Dilated fallopian tube lumen, lined by ciliated epithelium, attenuated or rare plicae, well developed smooth muscle in the wall, Lined by simple cuboidal to columnar epithelium with ciliated cells, sometimes admixed with nonciliated cells, Epithelial proliferation with architectural complexity, including branching of irregularly shaped papillae, Lined by epithelium with 2 or more Mllerian cell types each accounting for at least 10% of the epithelium (, Frequently associated with endometriosis (. ovary Expand All | Collapse All. Pathology Atlas: Ovary | GLOWM We welcome suggestions or questions about using the website. Each category includes a number of subtypes. Contents 1 Normal ovary 1.1 Images 2 Cysts - overview 2.1 General 3 Specific benign diagnoses 3.1 Endometriosis 3.2 Corpus luteum cyst 3.2.1 General 3.2.2 Gross 3.2.3 Microscopic 3.3 Benign mesothelial inclusion cyst It is a significant part of gynecologic pathology. Other ovarian specific tumors: small cell carcinoma of ovary, hypercalcemic type small cell carcinoma of ovary, pulmonary type. gastric mucinous adenocarcinoma pathology outlines. We have rearranged our websites menus to put the most important pages on the top line, which remains fixed as you scroll down. Serous Papillary Cystadenoma of Ovary is a common benign ovarian tumor that generally affects middle aged women (40-60 years old). Pathology Outlines is a multi-authored online textbook covering a wide range of topics with macroscopic and microscopic pathology images. Most tumors of the ovary can be placed into one of three major categories surface epithelial-stromal tumors, sex cord-stromal tumors, and germ cell tumors (Fig. Ovaries, omentum, fallopian tube serosa, uterine serosa, bladder, lymph nodes Pathophysiology Multiple hypotheses, including distal fallopian tube implants in the ovarian cortex during ovulation or metaplastic changes of the ovarian surface epithelium or peritoneal cells ( Reprod Sci 2013;20:1030) Copyright PathologyOutlines.com, Inc. Click, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). [5] +/-Papillary infoldings. (, Tumors with endometrioid appearance in uterus and ovary are probably independent, have excellent prognosis, Metastases from cervix to ovary likely if bilateral ovary involvement, extensive extracervical disease and microscopic type is unusual for ovary, such as squamous or small cell, Other tumor histology often signifies metastases with poor prognosis, Most childhood ovarian tumors are benign (> 90%) and cystic; malignant tumors have favorable outcome with chemotherapy, even after recurrence (, Usually present as unilateral mass without metastases (. Contributed by Catherine J. Roe, M.D. Pure mature teratomas and pure immature teratomas do not have this changes. Pathology Outlines - Ovary tumor overview Contents. 11,826 Images : Last Update : Nov 19, 2022. These finding represent a benign serous cystadenoma with focal epithelial proliferation. (, Metastasis from endometrial tumor to ovary is more likely if multinodular, bilateral, small ovarian tumors, tubal lumen involvement is present, deep myometrial invasion or myometrial vascular invasion is present Endometriotic Cyst (Chocolate Cyst) of Ovary High Quality Pathology Images of Gynecologic, Ovary, Miscellaneous Ovarian Lesions. Webpathology.com: A Collection of Surgical Pathology Images Multiple variably sized cysts and cystic follicles, Atretic follicle with bands of luteinized theca cells, Bands of luteinized theca cells with hemorrhage, Outer cortex iscollagenized withseveral follicle cysts. Ovary Pathophysiology Neoplastic transformation of ovarian stromal cells due to hereditary or sporadic genetic abnormalities (see Molecular / cytogenetics description ) Clinical features Most commonly symptoms related to an ovarian mass, such as abdominal pain or distension and increased urinary frequency or may be incidental Sign out Mature teratoma Mass, Right Ovary, Excision: - Mature teratoma with dermal elements and mature neural tissue. Around 80% of mucinous carcinomas of the ovary are metastatic, with approximately 80% of primary tumors being stage I. WebPathology is a free educational resource with 11,826 high quality pathology images of benign and malignant neoplasms and related entities. Apps; Surgpath gyn ovary. Mesothelioma Of Ovary Pathology Outlines - E Jurnal This website is intended for pathologists and laboratory personnel but not for patients. Ovary : Mixed germ cell tumours of the ovary also typically have i (12p). Sarcomatous component is poor prognostic sign ( Am J Surg Pathol 2007;31:1356 ) Good prognostic factors for nonseminomatous tumors: rapid decline in serum AFP or hCG after surgery and chemotherapy, no vascular invasion . Copyright PathologyOutlines.com, Inc. Click, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). This website is intended for pathologists and laboratory personnel but not for patients. On physical examination, she's noted to have hirsutism, central obesity (BMI of 35) and acne. Comment: The 8.3 cm cystic ovarian mass was extensively sampled. Borderline tumours usually affect women aged between 20 and 40. It may be seen in isolation or in association of. 7.7 Seromucinous borderline tumour of the ovary 7.7.1 General 7.7.2 Gross 7.7.3 Microscopic 7.8 Mucinous cystadenoma of the ovary 7.9 Mucinous borderline tumour of the ovary 7.10 Mucinous adenocarcinoma of the ovary 7.11 Endometrioid carcinoma of the ovary 7.12 Clear cell carcinoma of the ovary 7.13 Transitional cell carcinoma of the ovary May be associated with a BRCA1 gene or BRCA2 gene mutation. Pathology Outlines - Fibroma Borderline Mucinous Cystadenoma Ovary Pathology Outlines It is important to distinguish treatment-related atrophy from senescence, and atrophic lesions associated with senescence should not be diagnosed. Nov 19, 2022. of and to in a is " for on that ) ( with was as it by be : 's are at this from you or i an he have ' not - which his will has but we they all their were can ; one also the Serous cystadenoma with focal epithelial proliferation. Copyright PathologyOutlines.com, Inc. Click, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). This website is intended for pathologists and laboratory personnel but not for patients. However, we cannot answer medical or research questions or give advice. They are usually diagnosed at an early stage. 3. BRCA1 germline mutations cause 50% lifetime risk of ovarian cancer at average age of ~50 years BRCA2 germline mutations causes lower lifetime risk (10 - 35%) at a later age (average ~55 years) Associated with homologous recombination defects Hereditary predisposition in 6% of women with Fanconi anemia Copyright PathologyOutlines.com, Inc. Click, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). This is when the abnormal cells are still within the ovary. epithelium. Ovarian parenchyma can largely be divided into 3 compartments: Albuginea: a protective hypocellular compartment, composed of a fibrotic layer measuring approximately 0.3 mm and occupying the most superficial part of the ovary (, Cortex: a 0.3 mm hypercellular layer composed of spindle cells arranged parallel to the surface and housing the majority of the follicles in a premenopausal woman (, Medulla: a hypocellular area beneath the cellular cortex and housing abundant blood vessels; nodular or diffuse proliferation of spindle cells can commonly be seen in the medulla (, Resembles fibroblasts in whorls / storiform pattern surrounded by dense reticulin network, Contains luteinized stromal cells, decidual cells, smooth muscle, fat, neuroendocrine cells and endometrial stroma-like cells, Ovarian parenchyma can alternatively be defined as the ovarian follicles, given that the follicles are the constituents that perform the function of the ovary with all the other constituents being labeled as ovarian stroma (, Number of primordial follicles and oocytes in premenopausal women can be markedly different between the 2 ovaries (, Within the same ovary, the primordial follicles and oocytes exhibit an uneven distribution in the cortex with clustering in few areas (, In addition to their more common location in the cortex, the primordial follicles can be seen in the medulla within areas of nodular proliferations, especially in women with abundant follicular cysts (, Follicle is designated cystic when it measures 2 mm or more but less than 9 mm; these are very common and can be lateralized to 1 ovary in some individuals (, Diplotene oocyte surrounded by a layer of flattened granulosa cells (, Oocyte with surrounding granulosa cell layer, Contains Call-Exner bodies (rosette-like formations with central filamentous / eosinophilic material consisting of excess basal lamina) and theca cells (within follicle are luteinized and produce sex hormones, external to follicle are very cellular), 2 cm, round to serpiginous, yellow, lobulated structure with cystic center, In pregnancy, is larger, bright yellow with prominent central cavity, hyaline droplets and calcification, Corpus albicans: remnant of corpus luteum, hyalinized, paucicellular fibrotic scar with serpiginous contours, Ovarian surface epithelium (OSE) is a modified mesothelium, also called coelomic or germinal epithelium (, Single layer of flat to cuboidal mesothelial type cells, which appear to actively participate in the ovulatory rupture and repair process (, Closely related to Mllerian duct lining epithelium, Superficial cysts that are lined by mesothelial cells and represent invagination of the surface mesothelial epithelium, Group of glands and cysts with a tubal epithelial lining, Usually seen in ovaries without clefts and commonly associated with calcification, Rim of fibrotic tissue can surround them (, In contrast to inclusion cysts, their presence can be associated with the recurrence of low grade serous neoplasms (, Located in ovarian medulla, rarely within ovarian stroma; located away from the hilum, round to polygonal, epithelial appearing, presumed vestigial remnant of gonad from its ambisexual phase, Closely associated with large hilar veins and lymphatics and may protrude within their lumina; also associated with nerves, May contain Reinke crystalloids, lipid, lipochrome pigment, Resemble steroid cells by electron microscopy with microtubular smooth endoplasmic reticulum, mitochondria with tubular cristae, Hilar cells are seen in the fetal ovary but not in infancy and childhood; they reappear at puberty, Hilar cell hyperplasia: associated with hCG administration, pregnancy and choriocarcinoma, Seen as clefts, tubules, cysts, papillae lined by cuboidal or columnar epithelium, Located usually in the hilum of the ovary, surrounded by spindle cell stroma, Usually microscopic cystic / solid structures with urothelial type epithelium and variable mucin seen in mesovarium, mesosalpinx and ovarian hilus, Ovary can house stem cells for variable cell types with both somatic and germline stem cells being mentioned, Somatic stem cells include granulosa cells, surface epithelial cells, thecal cells and stromal cells (, Common incidental finding in the ovaries of late reproductive and postmenopausal women, composed of an aggregate of epithelioid histiocytes surrounded by a rim of lymphocytes, They are of uncertain origin but could represent previous areas of endometriosis, luteinized stromal cells or ectopic decidua (, Can show significant difference in the composition between the right and left side (, Its presence is permanent and does not depend on the phase of the menstrual cycle or the age of the patient, Surgical removal of the ovary is indicated to prevent metastasis, The image represents a physiologic constituent of the ovary, The image represents a sex cord stromal tumor, Benign tubular structures located within the ovarian cortex; constituent cells are positive for mesothelial markers, Benign polygonal cells with clear cytoplasm, round nucleus and positive staining for inhibin and calretinin, Epithelial cell proliferation composed of papillary structures lined by cuboidal cells and exhibiting hierarchical branching and tufting of the lining cells, Urothelial-like nests of cells known as Walthard nests. They vary in size and may occur at different sites in the ovary; the most common type develops when an egg-producing follicle does not rupture and release the egg but. The ovary has a wealth of pathology. Teratoma - Libre Pathology Aug 5, 2017. Normal. Visual survey of surgical pathology with 11,826 high-quality images of benign and malignant neoplasms & related entities. female pseudohermaphroditism associated with congenital adrenal hyperplasia, surface epithelial tumors-overview / molecular, large solitary luteinized follicular cyst of pregnancy and puerperium, mucinous borderline tumor / atypical proliferative mucinous tumor, primary retroperitoneal mucinous cystadenoma, mural nodules in mucinous cystic neoplasms, undifferentiated / dedifferentiated carcinoma (ovary / endometrium), mixed germ cell - sex cord stromal tumor, unclassified (pending), small cell carcinoma of ovary, hypercalcemic type, small cell carcinoma of ovary, pulmonary type, neuroendocrine carcinoma (non-small cell type). Ovary - Atrophy - Nonneoplastic Lesion Atlas - National Toxicology Program What feature distinguishes cystadenoma from cortical inclusion cyst? Crum: Diagnostic Gynecologic and Obstetric Pathology, 3rd Edition, 2017, Cochrane Database Syst Rev 2007;3:CD001122, Nonclassical congenital adrenal hyperplasia, eMedicine: Polycystic Ovarian Syndrome [Accessed 2 November 2022], eMedicine: Imaging in Polycystic Ovary Disease [Accessed 2 November 2022], ACOG: Polycystic Ovary Syndrome [Accessed 2 November 2022], Polycystic ovarian syndrome (PCOS) is a clinicopathologic syndrome comprising polycystic ovaries and characteristic clinical features, Polycystic ovaries resembling PCOS may be seen in prepubertal period or puberty without clinical manifestations, Most common cause of anovulatory infertility, Presents with a variety of clinical and radiologic findings, Grossly enlarged, multicystic ovaries, although may not be enlarged in adolescent patients, Microscopically: ovaries with multiple cysts, hyperthecosis and atretic follicles, Associated with endometrial hyperplasia and endometrial neoplasia, Affects 4 - 12% of women in the U.S., usually of teenage or childbearing ages (, Development of insulin resistance and hyperandrogenism in polycystic ovary disease is not fully understood, Familial clustering of cases has been observed, strongly suggesting a genetic basis for polycystic ovary disease; however, no specific genetic abnormality has been shown to be the sole culprit in the development of polycystic ovary disease, Presents with menstrual disorders (from amenorrhea to menorrhagia) and infertility, Can cause acne, obesity, hirsutism, insulin resistance and diabetes, National Institutes of Health (NIH) (1990): androgen excess, oligoovulation and exclusion of other entities that cause polycystic ovaries. Glial Tumors . Polycystic ovarian syndrome (PCOS) is a clinicopathologic syndrome comprising polycystic ovaries and characteristic clinical features Polycystic ovaries resembling PCOS may be seen in prepubertal period or puberty without clinical manifestations Essential features Most common cause of anovulatory infertility The ovarian stroma is more abundant in the medulla, where the larger follicles are seen. However, we cannot answer medical or research questions or give advice. An ovarian cyst is a fluid-filled sac that forms in the ovary. limited to ovary(s) T1a: unilateral; T1b: bilateral; T1c: tumor ruptured, on surface, or in peritoneal fluid. . European Society of Human Reproduction and Embryology / American Society of Reproductive Medicine (ESHRE / ASRM) in Rotterdam (2003) (2 of 3 present): Excess androgen activity (clinical or biochemical signs), Polycystic ovaries present (by ultrasound) but no other endocrine disorders. Home; Slides Slide Index. Ovarian cysts are common and, in the vast majority of cases, they are benign (noncancerous). However, we cannot answer medical or research questions or give advice. Mesothelioma pathology january 13, 2022. Accessed November 19th, 2022. We have rearranged our websites menus to put the most important pages on the top line, which remains fixed as you scroll down. Mesothelioma Of Ovary Pathology Outlines Mesothelioma Of Ovary Pathology Outlines. Slide Index Categories . They are also more common in postmenopausal women. Pathology Outlines - Serous cystadenoma / adenofibroma We have rearranged our websites menus to put the most important pages on the top line, which remains fixed as you scroll down. Neuropath. We welcome suggestions or questions about using the website. Ovary - Atrophy should be recorded and graded only when treatment related. Metastases to ovary: metastases to ovary appendiceal neoplasms breast carcinoma carcinoid tumor metastatic to ovary cervical carcinoma metastatic to ovary colorectal adenocarcinoma upper gastrointestinal tract. Kurman: Blaustein's Pathology of the Female Genital Tract (Springer Reference), 7th Edition, 2019, Paratubal Mllerian cyst (hydatid cyst of Morgagni), Int J Gynecol Pathol 2021 Feb 11 [Epub ahead of print], WHO Classification of Tumours Editorial Board: Female Genital Tumours, 5th Edition, 2020, Crum: Diagnostic Gynecologic and Obstetric Pathology, 1st Edition, 2011, Benign partially or completely cystic lesion measuring > 1 cm in size and composed of cells resembling fallopian tube epithelium or cuboidal nonciliated epithelium resembling ovarian surface epithelium, Benign; > 1 cm in size (< 1 cm signifies a cortical inclusion cyst); composed of cells resembling fallopian tube epithelium, Presents over a broad age range and are generally asymptomatic, Usually small, uni to multilocular cysts lined by a single layer of tall, columnar, ciliated cells, Adenofibromas and cystadenofibromas are composed predominantly of fibrous stroma, with glands and cysts forming a minor component, Includes cystadenoma, cystadenofibroma, adenofibroma, papillary cystadenoma, papillary cystadenofibroma, papillary adenofibroma, Term used depends on the relative amount of fibrous stroma but distinctions are often arbitrary, Most often found in adult women of reproductive age, DNA copy number changes may be seen in stromal fibromatous cells and epithelial cells (, One of the more common ovarian tumors to undergo torsion, CA-125 levels may be mildly elevated (rarely marked) (, Typically anechoic with thin, smooth walls and posterior acoustic enhancement; unilocular cysts, thin walls, minimal septations and absence of papillary projections (, Imaging modality: pelvic ultrasound or CT scan, 63 year old woman with ruptured benign serous ovarian cystadenoma mimicking ovarian malignancy with peritoneal carcinomatosis (, 64 year old woman with bilateral ovarian fibromas and concomitant unilateral serous cystadenoma (, 65 year old woman with ovarian serous cystadenoma with ectopic adrenal tissue (, Usually 3 - 10 cm (but can be up to 30 cm), oval to round, smooth glistening surface, Usually watery clear to pale yellow cyst fluid but can be viscous and mucoid, Rarely papillary excrescences are seen on outer surface, Varies from solid areas with knobby papillae to firm confluent areas, Uni or multiloculated cysts with single layer of cuboidal or columnar epithelium and simple papillary projections, if present, Bland appearing fibrous stroma in varying amounts, No invasion, architectural complexity or atypia, Usually small, uni to multilocular cysts lined by a single layer of tall, columnar, ciliated cells resembling normal tubal epithelium or cuboidal nonciliated epithelium resembling ovarian surface epithelium, If < 10% of the total tumor volume shows epithelial proliferation within the cysts that would otherwise qualify as serous borderline tumor, the tumor is designated as serous cystadenoma with focal epithelial proliferation, Groups, strips or clusters of epithelial cells with small, bland, round to oval nuclei and variable cytoplasm with or without cilia, Background cyst contents, including histiocytes and proteinaceous debris, Cannot definitively diagnose on a cytology specimen; histologic examination is required for classification, Serous cystadenoma with focal epithelial proliferation (see comment). //Pathologyapps.Com/Ovary-Outlines.Php '' > Teratoma - Libre pathology < /a > Aug 5, 2017 typically i. 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